I was recently asked where exactly in the New 52 does Harley Quinn break away from the Joker. I was happy to find this little gem from Harley Quinn Vol. 2 #25.
This is such an important scene for Harley. This is where she finally becomes her own person, for good. She makes the shift to antihero and cuts her ties with the her Puddin’.
So now, ladies and gents, for your viewing pleasure: Harley Quinn vs The Joker!